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Isoliquiritigenin

 
Product Name Isoliquiritigenin
Latin Name Isoliquiritigenin
Molecular Formula C15H12O4
Molecular Weight 256
CAS NO 961-29-5
Appearance White powder
Product Content ≥98%  
Analytical Method HPLC
   
Product Origin

Glycyrrhiza uralensis Fisch.; Glycyrrhiza inflata Bat.; Glycyrrhiza glabra L.

   
Action and Uses Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts. The effect of isoliquiritigenin on cell proliferation and cell cycle progression was examined in the A549 human lung cancer cell line. Isoliquiritigenin significantly inhibited the proliferation of lung cancer cells in a dose- and time-dependent manner. Flow cytometric analysis demonstrated that isoliquiritigenin restrained the cell cycle progression at G2/M phase. Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21CIP1/WAF1, a universal inhibitor of cyclin-dependent kinases. These results suggest that isoliquiritigenin will be a promising agent for use in chemopreventive or therapeutics against lung cancer.
Analysis
  Product content Isoliquiritigenin≥98%
Sieve analysis 100% pass 80 mesh
Loss on Drying ≤1.0%
Residue on Ignition ≤1.0%
Heavy Metal <20ppm
As <2ppm
Residual Solvents Eur.Pharm.2000
Microbiology  
Total Plate Count <1000cfu/g
Yeast & Mold <100cfu/g
E.Coli Negative
Salmonella Negative
     
Conclusion Conform with specification
   
Storage Store in sealed containers at cool & dry place. Protect from light,moisture and pest infestation
   
Shelf life 2 year when properly stored
 
 
 
    Hopeland Chem-Tech Co., Ltd.
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