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Isoliquiritigenin |
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Product Name |
Isoliquiritigenin |
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Latin Name |
Isoliquiritigenin |
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Molecular Formula |
C15H12O4 |
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Molecular Weight |
256 |
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CAS NO |
961-29-5 |
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Appearance |
White powder |
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Product Content |
≥98% |
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Analytical Method |
HPLC |
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Product Origin |
Glycyrrhiza
uralensis Fisch.; Glycyrrhiza inflata Bat.; Glycyrrhiza
glabra L. |
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Action and Uses |
Isoliquiritigenin is a natural flavonoid
isolated from licorice, shallot and bean sprouts. The effect
of isoliquiritigenin on cell proliferation and cell cycle
progression was examined in the A549 human lung cancer cell
line. Isoliquiritigenin significantly inhibited the
proliferation of lung cancer cells in a dose- and
time-dependent manner. Flow cytometric analysis demonstrated
that isoliquiritigenin restrained the cell cycle progression
at G2/M phase. Further examinations using cDNA arrays and
real-time quantitative RT-PCR revealed that
isoliquiritigenin enhanced the expression of p21CIP1/WAF1, a
universal inhibitor of cyclin-dependent kinases. These
results suggest that isoliquiritigenin will be a promising
agent for use in chemopreventive or therapeutics against
lung cancer. |
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Analysis |
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Product content |
Isoliquiritigenin≥98% |
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Sieve analysis |
100% pass 80 mesh |
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Loss on Drying |
≤1.0% |
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Residue on Ignition |
≤1.0% |
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Heavy Metal |
<20ppm |
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As |
<2ppm |
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Residual Solvents |
Eur.Pharm.2000 |
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Microbiology |
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Total Plate Count |
<1000cfu/g |
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Yeast & Mold |
<100cfu/g |
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E.Coli |
Negative |
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Salmonella |
Negative |
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Conclusion |
Conform with specification |
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Storage |
Store in sealed containers at cool & dry
place. Protect from light,moisture and pest infestation
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Shelf life |
2 year when properly stored |
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